Cancer cells, including glioblastoma (GBM) tumor cells that are highly resistant to all known therapies, express tumor specific receptors, IL-13RA2 and EphA2 (these receptors are not present in normal cells). ”

This breakthrough solution will be based on the use of therapy targeting IL-13RA2 and EphA2 receptors by genetically modified IL-13 and Ephrin 1 proteins, conjugated to Pseudomonas and Diphtheria bacteria toxins. Recombinant IL-13 and Ephrin 1 proteins armed with potent bacteria toxins preferentially bind to GBM tumor-specific receptors and deliver highly cytotoxic payload. This highly specific targeting of GBM cells will allow for selective elimination of tumor cells by bacteria-toxins-induced cytotoxic effects without affecting normal cells. Furthermore, the planned method of administering the drug to the tumor tissue will be an advantage over standard intravenous administration, resulting in the possible reduction of any potential side effects associated with standard chemotherapy. Development of WPD101 will allow GBM patients access to innovative molecular targeted therapies as an alternative to conventional treatment.